Fluorescent nucleosides for labeling of DNA and RNA probes

Required Availability
The End of Time
Course Credit?
Yes - CH396
Paid Position?
No
Preferred Majors
Biochemistry | Biochemistry/Biology | Biochemistry/Chemistry | Chemical Engineering | Chemistry
Faculty
Stephen Woski
Keywords
DNA | RNA | fluorescence
Description

Using non-natural nucleoside analogues, we explore the structures of nucleic acids (DNAs and RNAs), molecules that play central roles in the storage and expression of biological information. Our approach utilizes synthetic chemistry to prepare fluorescent nucleosides. Incorporation of these residues into short strands of DNA and/or RNA will produce molecules that report the presence of complementary nucleic acid sequences. When these sequences are unique to a pathogen or disease state, the probe molecules can be used diagnostic medical tests.

Contact Phone #
N/A
Contact Email
swoski@ua.edu
Research Website
N/A
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